So I just downloaded and tested it for about 10 minutes and it runs great so far. The biggest thing for me is that I have yet to encounter a non-kanto pokemon (I'm only in viridian but still). Some of the sprites for froakie (I chose froakie) are still swapped with squirtle and the cries are still set to squirtle. Chespin only knew struggle and actually forced me to use a potion to beat. Other than that it runs great so far.
edit: and now my save file is gone! apparently it never saved.
For roms period, saving is an issue. You normally have to work with your settings on your emulator to be able to successfully save. If you don't want to look that up, I'll suggest using save states, as they are really useful.